Melt-extrusion multiparticulates
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United States of America Patent
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Jan 1, 2002
Issued Date -
N/A
app pub date -
Jul 22, 1999
filing date -
Nov 4, 1994
priority date (Note) -
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Abstract
A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
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