Production of 8,8a-dihydroxy-6-deoxyerythronolide B
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United States of America Patent
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May 14, 2002
Grant Date -
Oct 25, 2001
app pub date -
Jan 23, 2001
filing date -
Oct 29, 1998
priority date (Note) -
Expired
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Abstract
The heterologous expression of the OlePKS in Streptomyces lividans, produces 8,8a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with DEBS in S. lividans of the P450 monooxygenase OleP produces 8,8a-dihydroxy-6-deoxyerythonolide B and other derivatives that are precursors to important macrolide antibiotics.
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