Proteoliposomes containing an integral membrane protein having one or more transmembrane domains
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United States of America Patent
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-
Jul 13, 2004
Grant Date -
Oct 25, 2001
app pub date -
Dec 27, 2000
filing date -
Dec 30, 1999
priority date (Note) -
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Abstract
A stable proteoliposome containing an integral membrane protein in a lipid membrane around an elliptoid or spherical shape. The shape preferably contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The integral membrane protein is bound to a ligand which is anchored in the shape. Methods for making the proteoliposomes are provided. Kits for making the proteoliposome are described, as are the uses of the proteoliposome.
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