Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
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United States of America Patent
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Oct 7, 2003
Grant Date -
Nov 1, 2001
app pub date -
Dec 21, 2000
filing date -
Dec 29, 1999
priority date (Note) -
Expired
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Abstract
A cytotoxic agent comprising one or more modified doxorubicins/daunorubicin linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more modified doxorubicins/daunorubicins covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more modified doxorubicins/daunorubicins linked to a cell binding agent. Novel sulfur-containing modified doxorubicins/daunorubicins.
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