Muscarinic receptor agonists
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United States of America Patent
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Apr 23, 2002
Grant Date -
Nov 1, 2001
app pub date -
Jan 29, 2001
filing date -
Jan 22, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A compound of Formula (III): ##STR1## wherein X is a linkage independently selected from (CH.sub.2).sub.12 or (CH.sub.2 CH.sub.2).sub.4 O.sub.3 and wherein R.sub.3 is independently selected from H, CH.sub.2 CH.sub.3, COCH.sub.3 or ##STR2## and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
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