Chimeric oligonucleotides and the use thereof
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United States of America Patent
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app pub date -
Mar 26, 2001
filing date -
May 2, 1997
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Abstract
The invention relates to novel chimeric oligonucleotides and their use, especially to bind and inhibit the enzyme telomerase. The oligonucleotides were prepared in view of RNA's non-binding activity to phosphorothioates and the primer binding site of the enzyme. The oligonucleotides bind to the primer binding site thereby resulting in maximum inhibition of the enzyme.
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