Method for pulmonary and oral delivery of pharmaceuticals
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United States of America Patent
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-
Sep 9, 2003
Grant Date -
Nov 15, 2001
app pub date -
Jul 17, 2001
filing date -
Jan 10, 2000
priority date (Note) -
In Force
status (Latency Note)
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Abstract
In a powder formulation for use in a dry powder inhaler, a pharmaceutical acts as its own carrier, so that use of lactose or other excipients are not needed. The dry powder formulation has a single active pharmaceutical compound having two major populations in particle size distribution: microfine particles of the active pharmaceutical, of 1-10 microns in diameter, and larger carrier particles, also of the active pharmaceutical compound. The carrier particles provide a long acting, delayed onset, and optionally therapeutic effect via the GI tract, while the microfine particles provide a fast onset effect via the lung.
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