Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
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United States of America Patent
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Dec 3, 2002
Grant Date -
Nov 22, 2001
app pub date -
Dec 18, 2000
filing date -
Dec 17, 1999
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Abstract
A process is provided for labeling with signal amplification a ribonucleic acid (RNA), comprising fragmenting the RNA to form RNA fragments, fixing a first ligand to a terminal phosphate located at least one of the 3' end and the 5' end of each of a plurality of the RNA fragments, the terminal phosphate having been released during the fragmentation, and binding a plurality of labeling agents to the first ligand on each of a plurality of the fragments.
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