Methods for identifying inhibitors of methionine aminopeptidases
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United States of America Patent
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Jul 15, 2003
Grant Date -
Nov 29, 2001
app pub date -
May 24, 2001
filing date -
Oct 14, 1999
priority date (Note) -
Expired
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Abstract
Methods are provided for detecting methionine aminopeptidase (MAP) activity and for detecting inhibitors of MAP. The methods utilize a peptide comprising an N-terminal methionine which can be cleaved from the peptide by MAP, and a C-terminal detection moiety which is released by a second peptidase only if the N-terminal methionine has been cleaved from the peptide. When the peptide is combined with MAP and the second peptidase, the detection moiety is released, while the addition of a MAP inhibitor will inhibit the release of the detection moiety. Reaction mixes, peptides, and kits which are useful for practicing the methods are also provided.
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