Targeted immunostimulation with bispecific reagents

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United States of America Patent

SERIAL NO

09899384

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Abstract

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Disclosed are methods of stimulating in a subject an immune response to an antigen to which the immune response is targeted. This method includes the step of administering to the subject a binding agent which binds a surface receptor of an antigen-presenting cell, in some instances without being blocked substantially by the natural ligand for the surface receptor, and an antigen to which the immune response is targeted, in a physiologically acceptable medium to the subject. Also disclosed are molecular complexes including the binding agent coupled to an antigen.

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Patent Owner(s)

Patent OwnerAddress
MEDAREX INC1545 ROUTE 22 EAST P O BOX 992 ANNANDALE NJ 08801-0992 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fanger, Michael W Lebanon, NH 15 270
Gosselin, Edmund J North Haverhill, NH 7 28
Guyre, Paul M Hanover, NH 15 259
Romet-Lemonne, Jean Loup Gif-Sur-Yvette, FR 4 27

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