Intermolecular multiple-quantum coherence MR imaging in humans
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United States of America Patent
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Mar 4, 2003
Grant Date -
Dec 13, 2001
app pub date -
Mar 20, 2001
filing date -
Mar 20, 2000
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Expired
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Abstract
In nuclear magnetic resonance imaging of the human brain or the like, multiple quantum coherences, such as intermolecular double quantum coherence (iDQC) between water molecules, are used for soft tissue contrast. A group of pulse sequences are used in which, (a) The standard .beta.=.pi./2 pulse in the original CRAZED sequence is replaced with a .pi./3 pulse. The maximum signal derived from iDQCs is increased by a factor of 33/4. (b) The position of the acquisition window is adjusted, and a large acquisition window (small bandwidth) is used to sample a broad range of time-domain signals. (c) Receiver dynamic range is optimized. (d) A two-step phase cycle scheme for iDQC-encode gradients is designed to remove additional undesired coherence pathways.
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