Tissue bulking and coating compositions
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United States of America Patent
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Nov 25, 2003
Grant Date -
Dec 13, 2001
app pub date -
Mar 13, 2001
filing date -
Mar 13, 2000
priority date (Note) -
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Abstract
Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and hydrolyzed copolymers of vinyl acetate, for example, copolymers with vinyl chloride, N-vinylpyrrolidone, etc. The backbone polymer contains pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as agents to bulk and coat tissues.
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