Production and use of novel peptide-based agents for use with bi-specific antibodies
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United States of America Patent
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Nov 8, 2005
Grant Date -
Jan 17, 2002
app pub date -
Apr 3, 2001
filing date -
Jun 22, 1998
priority date (Note) -
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Abstract
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them.
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