Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies
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United States of America Patent
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Mar 28, 2006
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app pub date -
Jun 15, 1998
filing date -
Jun 17, 1997
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Abstract
According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps: a) isolating autologous tumor cells; b) treating the tumor cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumor cells with intact heterologous bispecific and/or trispecific antibodies showing the following properties: α—binding to a T cell; β—binding to at least one antigen on a tumor cell; γ—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.
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