Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
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United States of America Patent
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Issued Date -
Jan 24, 2002
app pub date -
Jun 19, 2001
filing date -
Jul 12, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention provides according to the first aspect thereof a human anti-.beta.-amyloid antibody obtained by purification from a human IgG-containing bodyfluid by A.beta.-affinity chromatography. In a second aspect the invention provides a method of purification of an anti-A.beta.-amyloid antibody, said method comprising the steps of obtaining a human IgG-containing bodyfluid, subjecting the bodyfluid obtained to an A.beta.-affinity chromatography, and recovering the purified anti-A.beta. antibody from the chromatography medium. Finally the invention provides for use of the above anti-A.beta. antibody for diagnosing and/or treating amyloid associated diseases, especially Alzheimer's disease and for a pharmaceutical composition comprising said antibody for treatment of Alzheimer's disease.
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