Ternary ligand complexes useful as radiopharmaceuticals
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United States of America Patent
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Mar 18, 2003
Grant Date -
Jan 31, 2002
app pub date -
Apr 5, 2001
filing date -
Apr 7, 2000
priority date (Note) -
Expired
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Abstract
This invention relates to novel highly functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals. Also, this invention provides radiopharmaceuticals comprised of highly functionalized phosphine ligated .sup.99m Tc labeled HYNIC-conjugated biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer.
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