Adenoviral vectors for mutants of human interleukin 6 (hIL-6) with hIL-6 antagonist activity, pharmaceutical compositions therewith and their uses
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United States of America Patent
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Nov 5, 2002
Grant Date -
Jan 31, 2002
app pub date -
Jun 30, 1999
filing date -
Sep 24, 1996
priority date (Note) -
Expired
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Abstract
The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction.
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