Recombinant attenuation of porcine reproductive and respiratory syndrome (PRRSV)
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United States of America Patent
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Issued Date -
Jan 31, 2002
app pub date -
Jan 26, 2001
filing date -
Jan 26, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates to live PRRS viruses which are attenuated by amino acid mutations in a specific site of the viral protein coded by the open reading frame (ORF) selected from the group of ORF 1a, ORF 1b and/or ORF 2. The invention also pertains to nucleotide sequences coding said viruses, methods of generating such viruses and their use for the preparation of a pharmaceutical composition for the prophylaxis and treatment of PRRS infections.
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