Methods for producing .alpha.-substituted carboxylic acids using nitrilases and strecker reagents
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United States of America Patent
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Nov 27, 2007
Grant Date -
Jan 31, 2002
app pub date -
Dec 28, 2000
filing date -
Dec 29, 1999
priority date (Note) -
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Abstract
In accordance with the present invention there are provided methods for producing enantiomerically pure .alpha.-substituted carboxylic acids, such as, for example, .alpha.-amino acids and .alpha.-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an anmionium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the enantiomerically pure .alpha.-substituted carboxylic acid, such as, for example, .alpha.-amino acids and .alpha.-hydroxy acids.
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