TERPYRIDINE-PLATINUM(II) COMPLEXES
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United States of America Patent
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Issued Date -
Jan 31, 2002
app pub date -
Jul 13, 1998
filing date -
Jan 26, 1996
priority date (Note) -
Abandoned
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Abstract
A new class of 2,2':6',2'-terpyridine-platinum (II) and substituted 2,2':6',2'-terpyridine-platinum (II) complexes in which an N-- or O-- or halo nucleophile is the fourth ligand to platinum. The compounds are potent intercalators of DNA. Some have antitumour activity. Some have anti-parasitic activity. A new method of preparing the complexes involves reacting a Pt complex of 1,5-cyclooctadiene with a 2,2':6',2'-terpyridine.
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