Cytotoxic agents comprising taxanes and their therapeutic use
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United States of America Patent
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Apr 16, 2002
Issued Date -
N/A
app pub date -
Aug 21, 2001
filing date -
Nov 24, 1999
priority date (Note) -
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Abstract
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
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