IL-12 enhancement of immune responses to T-independent antigens

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United States of America Patent

SERIAL NO

09924896

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Abstract

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The present invention relates to a method of modulating an immune response to a T-cell or thymus independent antigen in a host (e.g., mammalian, including human), comprising administering to the host an effective amount of interleukin-12 (IL-12) and the T-cell independent antigen. In one embodiment, the present invention relates to a method of inducing an immune response to a TI antigen in a host (e.g., mammalian, including human), which comprises administering to the host an effective amount of interleukin-12 (IL-12) and the TI antigen. In another embodiment, the present invention relates to a method of enhancing an immune response against a TI antigen in a host, which comprises administering to the host an effective amount of IL-12 and the TI antigen. The methods of the present invention can be used, for example, to induce and or enhance a humoral immune response (IgG2a and/or IgG3 humoral immune response).

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Patent Owner(s)

Patent OwnerAddress
THE MEDICAL COLLEGE OF OHIO3000 ARLINGTON AVENUE TOLEDO OH 43614

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buchanan, Renee M Toledo, OH 2 7
Metzger, Dennis W Sylvania, OH 5 27

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