COLONIC DELIVERY OF WEAK ACID DRUGS
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United States of America Patent
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Issued Date -
Feb 7, 2002
app pub date -
May 6, 1999
filing date -
Oct 4, 1996
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
There is provided a controlled release formulation including an inner core comprising, or coated with, a drug, which drug possesses (a) a free acid group which can be converted into an alkali metal salt and (b) a pKa in the rnage 2.0 to 9.0, which inner core is subsequently coated with a rate-controlling membrane that determines drug release, wherein the drug is present as a salt that displays higher solubility at pH 4.5 to 8.0 than the corresponding compound containing a free acid group.
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