CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
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United States of America Patent
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Jan 13, 2004
Grant Date -
Feb 14, 2002
app pub date -
Feb 22, 1999
filing date -
Oct 5, 1994
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Expired
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Abstract
A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less immunogenic in a heterologous host than, the parental murine monoclonal antibody A preferred murine Class III, anti-CEA monoclonal antibody is the MN-14 antibody and the preferred heterologous antibody is from a human. Also provided are DNA constructs and vectors for producing the humanized monoclonal antibodies, and diagnostic and therapeutic conjugates using same.
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