Compositions and methods for in vivo delivery of polynucleotide-based therapeutics
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United States of America Patent
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Apr 5, 2005
Grant Date -
Feb 14, 2002
app pub date -
Apr 23, 2001
filing date -
Apr 21, 2000
priority date (Note) -
Expired
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Abstract
The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides encoding such polypeptides. More particularly, the present invention provides the use of salts, in particular sodium and potassium salts of phosphate, in aqueous solution, and auxiliary agents, in particular detergents and surfactants, in pharmaceutical compositions and methods useful for direct polynucleotide-based polypeptide delivery into the cells of vertebrates.
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