Method for determining the presence of at least one allele of a GSTT1 deletion mutant
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United States of America Patent
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Apr 20, 2004
Grant Date -
Feb 21, 2002
app pub date -
Feb 22, 2001
filing date -
Feb 24, 2000
priority date (Note) -
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Abstract
Method for detecting the presence of at least one single allele of a deletion mutant, specially as PCR assay for detecting the presence of at least one GST1*0 allele wherein a PCR is performed with two primers, of which one stems from the sequence upstream of the deletion area, and the other stems from the sequence downstream of the deletion area and wherein the production of the corresponding DNA fragment in the PCR is checked. Useful for testing of patients to check whether they are susceptible to toxins or resistant or overly sensitive to certain therapeutic agents or belonging to risk groups.
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