Bioavailable dosage form of isotretinoin
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United States of America Patent
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May 25, 2004
Grant Date -
Feb 28, 2002
app pub date -
Apr 9, 2001
filing date -
Jun 16, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a bioavailable pharmaceutical composition of 13-cis vitamin A acid (also known as 13-cis retinoic acid and isotretinoin) and a process for preparing the same. 13-cis vitamin A acid is a relatively water insoluble compound that degrades when exposed to light and atmospheric oxygen. Due to its instability and relative insolubility, the bioavailability of the drug after oral administration is difficult to achieve and has always been a challenge to a development pharmacist. It would therefore be desirable to provide a dosage form in which the drug is stable and predictably bioavailable.
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