Recombinant adenovirus vectors that are replication-competent in tert-expressing cells
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United States of America Patent
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Sep 30, 2003
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app pub date -
Sep 19, 2001
filing date -
Jul 12, 1999
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Abstract
Novel adenovirus vectors which overexpress an adenovirus death protein and which are replication-competent in and, preferably, replication-restricted to cells expressing telomerase. One embodiment provides for efficient destruction and removal of viral-infected host cells expressing telomerase. Still further, another embodiment provides for additional restriction and safety by disrupting E1A's ability to bind p300 and/or members of the Rb family members. Compositions of the novel vectors and methods for promoting death of cells expressing telomerase with these vectors are also disclosed.
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