Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders
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United States of America Patent
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May 5, 2009
Grant Date -
Mar 21, 2002
app pub date -
Jun 14, 2001
filing date -
Jun 14, 2000
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Abstract
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with that association, the cascade of events associated with pleiotrophin activity can be prevented or reversed. Further, by evaluating the effect of different compounds and conditions on the interaction, new drugs and treatments can be identified for use in preventing certain cancers and growth and developmental disorders.
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