E.COLI PRODUCED IMMUNOGLOBULIN CONSTRUCTS
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
N/A
Issued Date -
Mar 28, 2002
app pub date -
Oct 23, 1991
filing date -
Oct 23, 1991
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
A method of producing recombinant heterotetrameric immunoglobulin from a procaryotic organism which includes providing a procaryotic organism that has been transformed with DNA encoding the heavy and light chains of an immunoglobulin having a binding site for immunologically binding a preselected antigen and an amino acid sequence which signals the export of the immunoglobulin from the cytoplasm of the organism, the DNA being operationally associated with a promoter recognizable by RNA polymerase endogenous to the organism, and culturing the transformed procaryote for a time and under conditions sufficient to allow the organism to export the immunoglobulin from the cytoplasm, wherein the exported heterotetrameric immunoglobulin retains its native conformation and binding specificity for the preselected antigen.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully