Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
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United States of America Patent
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Issued Date -
Apr 18, 2002
app pub date -
Mar 26, 2001
filing date -
Feb 2, 1999
priority date (Note) -
Abandoned
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Abstract
Described and claimed are compounds of the formula 1 wherein: Y is a polypeptide, R.sub.1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C.sub.1-21, alkyl, alkene, or alkyne group, R.sub.2 is a side chain of a naturally occuring amino acid, and X is 2 Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described are methods employing the compounds and antibodies.
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