Synthetic proteins for in vivo drug delivery and tissue augmentation
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United States of America Patent
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Apr 30, 2002
Grant Date -
Apr 18, 2002
app pub date -
Feb 24, 1997
filing date -
Mar 11, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Method and compositions are provided which are useful for delivering a biologically active substance to a localized site in vivo and for altering the physical dimensions of a body tissue. These method and compositions employ protein polymers having varying ratios of elastin-like collagen-like, keratin-like repeating units and repeating units which promote protein crystallization such as silk-like repeating units. By varying the length of segments of the repeating units and/or the concentration of the protein polymers in the composition, the rate of delivery of a biologically active substance to a localized site can be greatly varied. Moreover, because the compositions are capable of acquiring a non-liquid form under normal physiological conditions, they find use as biocompatible tissue augmentation products.
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