Oxamic acids and derivatives as thyroid receptor ligands
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United States of America Patent
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Apr 8, 2003
Grant Date -
Apr 25, 2002
app pub date -
Sep 27, 2001
filing date -
Mar 1, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides novel compounds of the Formula ##STR1## and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R.sup.1 -R.sup.8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.
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