In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Apr 25, 2002
app pub date -
Oct 24, 2001
filing date -
Oct 24, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.
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