High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
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United States of America Patent
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Issued Date -
Apr 25, 2002
app pub date -
Oct 10, 2001
filing date -
Oct 10, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.
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