Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6743820
APP PUB NO 20020052408A1
SERIAL NO

09900336

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Novel sulfate ester agents and the use of those agents for treating gastroesophageal reflux disease (GERD) are described, exemplary agents being of the formula: ##STR1## wherein X is --OCH.sub.2 -- or --CH.sub.2 O--; Y is a group pendant from X comprising at least one --OSO.sub.3 R.sup.4 moiety, wherein R.sup.4 is H or a pharmaceutically acceptable cation; n is an integer from 1-3; and R.sup.1 and R.sup.2 are each independently selected from the group consisting of --H, a halogen with an atomic number from 9 to 53, --SO.sub.3 R.sup.4, --NCS, --NCO, --NH(CO)--OR.sup.3, --NH(CS)SR.sup.3, --NH(C.dbd.NH)OR.sup.3, --NHCOCH.sub.2 Cl, --NHCOCH.sub.2 Br, --NHCO--CH.dbd.CH.sub.2, --NHC(O)--CF.sub.3, wherein R.sup.4 is H or a pharmaceutically acceptable cation.

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Patent Owner(s)

  • THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;THE UNIVERSITY OF TOLEDO

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hudson, Richard A Toledo, OH 6 1318
Orlando, Roy C New Orleans, LA 5 39
Tillekeratne, Liyanaaratchinge M V Toledo, OH 1 1
Tobey, Nelia A River Ridge, LA 4 25

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