Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
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United States of America Patent
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Jun 10, 2003
Grant Date -
May 16, 2002
app pub date -
Jun 22, 2001
filing date -
Jun 20, 1997
priority date (Note) -
Expired
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Abstract
The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
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