FIBRIN SEALANT AS A TRANSFECTION/TRANSFORMATION VEHICLE FOR GENE THERAPY
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United States of America Patent
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app pub date -
Jun 16, 1999
filing date -
Apr 30, 1998
priority date (Note) -
Abandoned
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Abstract
Provided, for example, is a method of transforming a cell comprising the steps of: applying a transformation effective amount of a nucleic acid to the cell; applying a fibrin gel to the cell so as to entrap a transformation effective amount of the nucleic acid; and transforming the cell with the nucleic acid. In one aspect, the nucleic acid is applied in admixture with a fibrin or fibrinogen composition that forms the fibrin gel.
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