Radiation sensitive liposomes

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6989153
APP PUB NO 20020064554A1
SERIAL NO

09728716

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Abstract

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The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONATUCSON, AZ308
VARIAN MEDICAL SYSTEMS, INC.PALO ALTO, CA282

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bondurant, Bruce Tucson, AZ 6 20
McGovern, Kathy A Tucson, AZ 5 13
O'Brien, David F Tucson, AZ 11 112
Sutherland, Robert Menlo Park, CA 17 155

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