Radiation sensitive liposomes

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6989153
APP PUB NO 20020064554A1
SERIAL NO

09728716

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONATUCSON, AZ314
VARIAN MEDICAL SYSTEMS, INC.PALO ALTO, CA282

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bondurant, Bruce Tucson, AZ 6 18
McGovern, Kathy A Tucson, AZ 5 11
O'Brien, David F Tucson, AZ 11 110
Sutherland, Robert Menlo Park, CA 17 143

Cited Art Landscape

Patent Info (Count) # Cites Year
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
* 6180135 Three-dimensional colorimetric assay assemblies 6 1997
 
ALLIANCE PHARMACEUTICAL CORP. (1)
* 5061484 Perfluorochemical emulsion with stabilized vesicles 23 1989
 
The United States of America as represented by the Secretary of the Navy (1)
* 5366881 Polymerizable lipids for preparing vesicles that controllably release an encapsulant 46 1993
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
VARIAN MEDICAL SYSTEMS, INC. (2)
* 2009/0304,589 RADIATION SENSITIVE LIPOSOMES 1 2008
8535712 Radiation sensitive liposomes 0 2012
 
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (2)
8808733 Method of controlled drug release from a liposome carrier 0 2010
9849087 Methods and compositions for X-ray induced release from pH sensitive liposomes 0 2012
 
RING PARTNER INC. (1)
* 2005/0266,796 Broadcast monitoring system and method for intelligent optimization 5 2005
* Cited By Examiner