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Abstract

A thermally sterilized bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a matrix of 11-19%, and preferably about 15-19% (w/w) or thermally sterilized gelatin. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS.RTM., bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; bone marrow extracts, vascular proliferation or regeneration growth factors, bone morphogenetic protein, TGF-.beta., PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii). The thermally sterilized gelatin may be a commercially available grade of gelatin which is both thermally and irradiatively sterilized.

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First Claim