Inflammation inducible hybrid promoters, vectors comprising them and uses thereof
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United States of America Patent
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Mar 22, 2005
Grant Date -
Jun 27, 2002
app pub date -
Mar 14, 2001
filing date -
Mar 14, 2000
priority date (Note) -
Expired
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Abstract
The present invention relates to the field of the regulation of the expression of genes and is based in particular on the use of constructs which make it possible to activate the transcription of a transgene in cells, tissues or organs under inflammatory conditions. The promoters of the invention preferably comprise a) a PPAR response element and b) the whole or part of the promoter of the PLA2sIIA gene. The invention also relates to vectors, cells and compositions comprising these promoters, as well as their use for the regulation of the expression of genes in vitro, ex vivo or in vivo.
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