Acellular biological material chemically treated with genipin
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United States of America Patent
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Apr 8, 2003
Grant Date -
Jul 11, 2002
app pub date -
Feb 4, 2002
filing date -
Nov 5, 1996
priority date (Note) -
Expired
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Abstract
A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
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