Non-human model of gestational and adult folate deficiency and uses thereof
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United States of America Patent
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N/A
Issued Date -
Jul 11, 2002
app pub date -
Sep 24, 2001
filing date -
Sep 22, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Disclosed is a genetically modified non-human animal that is a model for defective folate transport. Specifically the non-human animal comprises a genetic modification that results in decreased or absent expression and/or biological activity of the endogenous reduced folate carrier. The animal can be further modified by introduction into the genome of a nucleic acid molecule encoding the human reduced folate carrier. Such an animal can be used in methods to identify compounds useful for treating a variety of conditions associated with defective folate transport, or for the identification of anti-folate compounds useful for treating cancer. The animal can also be used to study the biochemical and molecular events associated with folate transport. Compounds identified using such a model are valuable for therapeutic treatments.
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