Rapid determination of protein global folds
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United States of America Patent
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Issued Date -
Jul 25, 2002
app pub date -
Oct 22, 2001
filing date -
Oct 20, 2000
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Abandoned
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Abstract
This invention provides a method for rapidly obtaining accurate three-dimensional structure of proteins including large or multi-sub unit proteins, using a combination of NMR analysis of backbone only .sup.13C, .sup.15N or .sup.13C and .sup.15N isotopically labeled proteins which are optionally also .sup.2H isotopically labeled in the C.alpha. position protons and residual dipolar coupling measurements in more than one partially aligned state.
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