Death domain containing receptor 5

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United States of America Patent

APP PUB NO 20020098550A1
SERIAL NO

10005842

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

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Patent Owner(s)

Patent OwnerAddress
WAFERMASTERS INCORPORATED246 EAST GISH ROAD SAN JOSE CA 95112

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gentz, Reiner L Silver Spring, MD 167 1542
Ni, Jian Rockville, MD 453 3498
Rosen, Craig A Laytonsville, MD 736 10813
Yu, Guo-Liang Darnestown, MD 243 2464

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