Insitu assay of substance in biological sample using labeled probe
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United States of America Patent
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Sep 24, 2002
Grant Date -
Aug 8, 2002
app pub date -
Sep 28, 2001
filing date -
Apr 28, 1998
priority date (Note) -
Expired
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Abstract
A method for analyzing an objective substance, comprising reacting a labeled probe with an objective substance on a biological sample, said probe comprising a label substance of the formula (I): ##STR1## wherein A.sup.1 is an aromatic group, R.sup.1 is a hydrogen or --COCH.sub.2 COC.sub.n F.sub.2n+1 and n is an integer of 1-6, which is bonded to a probe selected from the group consisting of nucleic acid, nucleic acid binding protein, low molecular ligand and receptor for ligand (except antibody) to give a fluorescent complex, reacting the complex with an objective substance on a biological sample and assaying fluorescence of the resultant fluorescent complex, a labeled nucleic acid probe and a labeled nucleotide. According to the method of the present invention, defects such as hindrance of fluorescence due to contaminant substance, low sensitivity and the like can be resolved, thereby enabling analysis on a tissue.
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