Methods of using mutant flt3-ligand polypeptides to induce cellular expansion
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United States of America Patent
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Jun 27, 2006
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app pub date -
Jul 16, 2001
filing date -
Jul 2, 1998
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Abstract
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.
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