Method and intravascular stent for reducing complications after implantation of an intravascular stent
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United States of America Patent
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Issued Date -
Aug 15, 2002
app pub date -
Feb 27, 2002
filing date -
Feb 13, 2001
priority date (Note) -
Abandoned
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Abstract
This invention relates to methods and arrangement for reducing complications after implantation of an intravascular stent and, more particularly, for reducing the risk of restenosis due to stent implantation. This is achieved by using 17beta-estradiol as vessel healing substance after implantation of an intravascular stent. The 17beta-estradiol can be coated onto an intravascular stent and be included in a drug elution system applied to the intravascular stent. This can be achieved by means of a surface coating process such as CVD process. 17beta-estradiol inhibits the growth of smooth muscle cells and stimulates the re-endothelialization after implantation of an intravascular stent. The present invention makes use of these effects in order to prevent restenosis and in-stent stenosis.
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