Method of inducing apoptosis in lymphoid cells
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United States of America Patent
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Jun 26, 2007
Grant Date -
Sep 12, 2002
app pub date -
Sep 21, 2001
filing date -
Sep 21, 2000
priority date (Note) -
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Abstract
A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.
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