Generation and use of signal-plexes to develop specific cell types, tissues and/or organs
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United States of America Patent
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app pub date -
Mar 13, 2002
filing date -
Dec 4, 2000
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Abstract
Methods of forming and using signaling complexes ('Signalplexes') expressed in specific tissues and organs during particular stages of development to predicably guide cell division, cell migration, differentiation of cells and/or formation of tissue or organ primordia in vitro. Signal-plexes induce stem cells to express the same tissue and organ phenotypes as those from which the Signal-plexes were derived. Each member of the family of Signal-plexes induces differentiation of phenotypes only of a specific tissue or organ. Endocrine and exocrine pancreas, liver, lung, kidney, heart, cartilage, vascular, tendon, ligament and bone cells are induced in stem cells by Signal-plexes derived from each of the foregoing tissues as shown by morphology, immunostaining, ELISA, and RT-PCR analysis.
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